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PI3K/AKT pathway regulates E-cadherin and Desmoglein 2 in aggressive prostate cancer.
Cancer Med. 2015 Aug;4(8):1258-71. doi: 10.1002/cam4.463. Epub 2015 May 29.
Cancer Med. 2015.
PMID: 26033689
Free PMC article.
This study aims to provide a comprehensive view of the role and regulation of cell-cell adhesion in prostate cancer aggressiveness by examining the functional implications of both E-cadherin and Desmoglein 2 (DSG2). ...This reduced expression may be regulated …
This study aims to provide a comprehensive view of the role and regulation of cell-cell adhesion in prostate cancer aggressive …
Expression of adhesion molecules and mucins in human and rhesus macaque gastrointestinal epithelial cells.
Zhang HY, Chang H, Fan XN, Zhang KD, Yu L, Cao Y.
Zhang HY, et al.
Histol Histopathol. 2011 Nov;26(11):1405-13. doi: 10.14670/HH-26.1405.
Histol Histopathol. 2011.
PMID: 21938678
In normal human gastrointestinal cells, zonula occludens-1 (ZO-1), alpha-catenin, beta-catenin, gamma-catenin and desmoglein-2 (DSG2) were located in the cytoplasmic membranes, whereas symplekin stained in the nuclei. ZO-1, the three catenins, and DSG2 were observed …
In normal human gastrointestinal cells, zonula occludens-1 (ZO-1), alpha-catenin, beta-catenin, gamma-catenin and desmoglein-2 (DSG2) …
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The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.
Koyama-Nasu R, Takahashi R, Yanagida S, Nasu-Nishimura Y, Oyama M, Kozuka-Hata H, Haruta R, Manabe E, Hoshino-Okubo A, Omi H, Yanaihara N, Okamoto A, Tanaka T, Akiyama T.
Koyama-Nasu R, et al.
PLoS One. 2013;8(1):e53710. doi: 10.1371/journal.pone.0053710. Epub 2013 Jan 10.
PLoS One. 2013.
PMID: 23326490
Free PMC article.
However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as gamma-catenin), a desmosomal linker protein. We fu …
However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell c …
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A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma.
Teh MT, Parkinson EK, Thurlow JK, Liu F, Fortune F, Wan H.
Teh MT, et al.
J Oral Pathol Med. 2011 Jan;40(1):67-76. doi: 10.1111/j.1600-0714.2010.00951.x. Epub 2010 Oct 4.
J Oral Pathol Med. 2011.
PMID: 20923451
Microarray data from a large panel of lines revealed that the transcript levels of DSG3, DSC2/3, DP, PG and PKP1 were reduced in ID and IC. Interestingly, DSG2 was up-regulated in MC. Reduction of DSG3 and up-regulation of DSG2 were found in two independent microarr …
Microarray data from a large panel of lines revealed that the transcript levels of DSG3, DSC2/3, DP, PG and PKP1 were reduced in ID and IC. …
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